منابع مشابه
Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death
Neurodegenerative diseases are (i) characterized by a selective neuronal vulnerability to degeneration in specific brain regions; and (ii) likely to be caused by disease-specific protein misfolding. Parkinson's disease (PD) is characterized by the presence of intraneuronal proteinacious cytoplasmic inclusions, called Lewy Bodies (LB). α-Synuclein, an aggregation prone protein, has been identifi...
متن کاملLipid peroxidation is essential for α-synuclein-induced cell death
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease. Here, we studied the effect of oligomeric α-Syn on one of the major markers of oxidative stress, lipid peroxidation, in primary co-cultures of neurons a...
متن کاملα-Synuclein Regulates Neuronal Cholesterol Efflux.
α-Synuclein is a neuronal protein that is at the center of focus in understanding the etiology of a group of neurodegenerative diseases called α-synucleinopathies, which includes Parkinson's disease (PD). Despite much research, the exact physiological function of α-synuclein is still unclear. α-Synuclein has similar biophysical properties as apolipoproteins and other lipid-binding proteins and ...
متن کاملEnhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease.
Parkinson disease (PD), a prevalent neurodegenerative motor disorder, is characterized by the rather selective loss of dopaminergic neurons and the presence of α-synuclein-enriched Lewy body inclusions in the substantia nigra of the midbrain. Although the etiology of PD remains incompletely understood, emerging evidence suggests that dysregulated iron homeostasis may be involved. Notably, nigra...
متن کاملTheaflavins stimulate autophagic degradation of α-synuclein in neuronal cells
Given the recent epidemiological evidence showing an inverse correlation between black tea intake and the risk of Parkinson’s disease, it is an intriguing possibility that theaflavins, major natural polyphenols contained in black tea, may have an anti-neurodegenerative action. In this communication, we show that theaflavins act stimulatingly on autophagy in neuronal cells. Treatment of murine N...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2009
ISSN: 1750-1326
DOI: 10.1186/1750-1326-4-9